The plasma membrane is capable of forming a selectively permeable barrier. These barriers are formed around the cells and also in the intracellular compartments.
The plasma membrane can maintain the concentration of ions inside the cell.
The plasma membrane allows communication between extracellular and extra-organelle space.
The plasma membrane can generate a signal in response to a stimulus that can create a change in the membrane potential.
Carrier molecules are the molecules that aid in the transport of biological compounds such as DNA, RNA, proteins, electrons, and also certain ions (solutes). The transport of compounds across the plasma membrane which takes place through the carrier molecule (usually a protein) is similar to the enzyme-substrate reaction. The compounds carried by the carrier proteins are delivered to the other side of the plasma membrane without altering the structure or composition. Each carrier protein has one or more than one binding site for the solute to bind. The carrier molecule undergoes certain conformational changes so that the solute which is being carried is exposed first to one side of the plasma membrane and then to the other side of the membrane. When all the binding sites of the carrier molecule are filled with the solutes, the rate of transport is maximum. It is represented as Vmax. This shows that when all the binding sites of the carrier molecules are occupied it is said to be a specific carrier and it is capable of undergoing a flip between two conformational states. When the rate of the transport is half of the maximum value, the carrier protein has a characteristic binding constant which is Km. The binding of the solute to the carrier molecule is blocked by either competitive or non-competitive inhibitors. Competitive inhibitors usually compete for the same binding site and therefore are not carried by the carrier molecules. Non-competitive inhibitors bind to different parts of the carrier molecule and alter the structure of the carrier molecule.
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