Recommended dietary allowance (RDA) is defined as the average dietary intake required to meet the body’s daily requirement. Fats and cholesterol both are lipids or triglycerides. Fats and cholesterol are triglycerides that are required for a variety of body functions. The fats are required for the production of energy and are also stored for future energy requirements. Moreover, they support cell growth also. At the same time, cholesterol is required to make various compounds of biological importance, such as estrogen, vitamin D, and testosterone. Like fats, cholesterol can also be stored in the body. Thus, both fats and cholesterol can be consumed under a specified quantity only. If consumed in excess, they may lead to various health conditions. There are two primary sources of liver cholesterol: dietary cholesterol (exogenous) and de novo (endogenous).
When one overeats trans and saturated fats, it leads to the production of too much low density lipoprotein (LDL-“bad cholesterol”) in the liver that deposits in arteries leading to blockage. Experts usually advise that trans-fats should be avoided and that saturated fats should be restricted to 10 percent or less. This means 200 calories (22 grams) or fewer of saturated fats per day for a person who eats 2,000 calories a day. The cholesterol intake must be restricted to 300mg per day.
Cholesterol does not mix with blood and flows in the bloodstream. Cholesterol has the maximum effect on arteries as its deposition leads to artery blockage and, thus, increases the risk of cardiovascular diseases (CVD). The main cause of mortality is CVD, with around one in four cardiopathic fatalities in the United States (US). Therefore, CVD is a common cause of death. The reports say that in the United States of America (USA), 610,000 people die of CVD. The hallmark of CVD is atherosclerosis, a chronic inflammatory disease that causes cholesterol and fibrous tissue to deposit into the artery walls and eventually causes the arterial lumen to thicken and become thin or blocked. Inflammation governs both the development of plaque and atherosclerosis thrombotic consequences. It was first proposed in 1968 that eating cholesterol might contribute to the risk of cardiac disorders.
The American Heart Association then approved the suggestion that dietary cholesterol should be restricted to 300 mg/day in the USA for healthy people and that eggs should be restricted to a maximum of three in a week. However, all scientific evidence and experimental data have failed to confirm the theory that dietary cholesterol raises the risk of CVD through blood cholesterol. Researchers have shown a reduction in the intake of endogenous de novo cholesterol as a compensating mechanism for the retention of homeostasis cholesterol as an increased intake of dietary cholesterol (exogenous).
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