Vitamin A is vital for health, promotes cell development, immune functioning, fetal growth, and is good for vision. Possibly the well-known function of vitamin A is its role in eye health and eyesight. Retinal, the effective form of vitamin A, joins with protein opsin to produce rhodopsin, a molecule essential for low-light vision and color vision. It likewise preserves and sustains the conjunctiva and cornea. Moreover, vitamin A keeps surface tissues, including the lungs, skin, intestines, inner ear, and bladder. It boosts immune functioning by promoting the mass and dividing the T-cells (a kind of white blood cell that shields the body from contagion). Furthermore, vitamin A promotes normal skin cells and fetal growth of both male and female reproduction.
Vitamin A forms and preserves strong teeth, soft and skeletal tissue, and skin and mucus membranes. Retinoic acid, a type of vitamin A, is required for gene transcription. Retinol is taken up by the cell and oxidized to retinaldehyde, which is then converted to retinoic acid by retinol dehydrogenases. Because retinoic acid works as a ligand for nuclear receptors, the conversion of retinal to retinoic acid is irreversible and hence strictly regulated. To regulate gene transcription, retinoic acid interacts with these nuclear receptors.
Deficiency of Vitamin A
Although deficiency of vitamin A is uncommon in advanced nations such as the US, it is prevalent in growing nations, as those populations might have confined availability of food sources of provitamin A carotenoids and preformed vitamin A. Vitamin A deficiency can cause acute health problems. As per World Health Organization (WHO), globally vitamin A deficiency is the major cause of avoidable blindness in kids. Vitamin A deficiency further enhances the acuteness and chance of mortality from diseases such as diarrhea and measles. Moreover, vitamin A deficiency increases the chance of anemia and mortality in pregnant women and adversely affects the fetus by hindering development and growth. Moderately acute manifestations of vitamin A deficiency are skin problems such as acne and hyperkeratosis. Some groups such as early newborns, people undergoing cystic fibrosis, and gestating or breastfeeding women in advanced nations are at greater hazard of vitamin A deficiency.
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