The enteral route of drug administration is the group of methods that allow the drug’s passage through the gastrointestinal tract. It involves the gastrointestinal tract (GI tract), stomach, small intestine, and large intestine for the absorption of the drug. It consists of three main ways, that is, oral, sublingual, and rectal.
Oral drug administration:
It is the most common way of administration of drugs in clinical settings and procedures.
The drug is provided through the buccal cavity through chewing or ingestion.
The primary site of absorption of the drug is the small intestine.
The bioavailability of the drug depends upon the drug absorbed by the epithelial cells of the small intestine.
However, most of the drug gets metabolized in the liver (first-pass effect). It is an easy, cost-effective method and can be given to any patient.
Administration of drugs is an integral part of any medical procedure. The drug administration process to the patient determines whether or not the patient gains any benefit from the drug. The drug may also have side effects, which also depend upon the administration technique. For example, several medicines, when given suddenly through intravenous, can have side effects like deafness. At the same time, penicillin, when provided orally along with food, will not get absorbed properly. Two main factors determine whether or not a drug reaches its target site, that is, bioavailability and the method of administration.
Bioavailability of the drug is the proportion of the drug that reaches the circulatory system and gets distributed further. Intravenous drugs have 100% bioavailability since they are injected directly into the bloodstream. At the same time, the administration method of the drug is the location where the drug is administered. It may be oral or intravenous and also depends on the patient’s choice and the pharmacodynamics and pharmacokinetics of the drug. The routes are classified into three main categories. It includes enteral, parenteral, and other routes. The enteral route of drug administration is the collection of techniques that permit the drug’s passage through the gastrointestinal tract. The parenteral route of drug administration is the technique that involves non-oral ways of providing the drug. Other drug administration methods include routes that do not involve either the venous supply or the gastrointestinal tract.
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